Prostate Cancer New Human Retrovirus Associated with Murine Leukemia Virus-Related Virus, a Integration Site Preference of Xenotropic
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Published Ahead of Print 6 August 2008. 2008, 82(20):9964. DOI: 10.1128/JVI.01299-08. J. Virol. A. Chow A. Klein, Christopher Lee, Robert H. Silverman and Samson Serena A. Lee, Jaydip Das Gupta, Christina Gaughan, Eric Sanggu Kim, Namshin Kim, Beihua Dong, David Boren, Prostate Cancer New Human Retrovirus Associated with Murine Leukemia Virus-Related Virus, a Integration Site Preference of Xenotropic
منابع مشابه
Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.
Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus identified in prostate cancer tissue from patients homozygous for a reduced-activity variant of the antiviral enzyme RNase L. Neither a casual relationship between XMRV infection and prostate cancer nor a mechanism of tumorigenesis has been established. To determine the integration site preferences of XMRV and ...
متن کاملFidelity of Target Site Duplication and Sequence Preference during Integration of Xenotropic Murine Leukemia Virus-Related Virus
Xenotropic murine leukemia virus (MLV)-related virus (XMRV) is a new human retrovirus associated with prostate cancer and chronic fatigue syndrome. The causal relationship of XMRV infection to human disease and the mechanism of pathogenicity have not been established. During retrovirus replication, integration of the cDNA copy of the viral RNA genome into the host cell chromosome is an essentia...
متن کاملXenotropic Murine leukemia virus-related virus (XMRV) in Iranian HIV Patients
Background: Despite of isolation of Xenotropic murine leukaemia virus-related virus (XMRV) from the patients acquired prostate cancer in 2006 and patients with chronic fatigue syndrome in 2009, there have been controversial findings about its potential role in human diseases and frequencies in different population groups. In the present study, we aimed to determine the frequency of XMRV genome ...
متن کاملMultiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells.
The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, most frequently in humans with a defect in the antiviral defense protein RNase L, suggesting a role for XMRV in prostate carcinogenesis. However, XMRV has not been found in prostate carcinoma cells. Here we show that 22Rv1 prostate carcinoma cells produce high-titer virus that is nearl...
متن کاملXenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.
Xenotropic murine leukemia virus-related virus (XMRV) is a gamma retrovirus that has been associated with chronic fatigue syndrome (CFS) and prostate cancer. The search for viral causes of these syndromes was reignited by the finding that RNase L activity was low in hereditary prostate cancer and some CFS patients. The six strains of XMRV that have been sequenced have greater than 99% identity,...
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تاریخ انتشار 2008